The purpose of the study was to prolong the gastric residence time of Repaglinide by designing its floating tablets and to study the influence of different polymers on its release rate. Formulations of Repaglinide containing varying concentrations of polymers were designed. The floating matrix tablets of Repaglinide were prepared by direct compression method. The prepared tablets were evaluated for physicochemical parameters such as hardness, floating properties (floating lag time, floating time and matrix integrity), swelling studies and drug content. The physicochemical parameters of formulated tablets were found to be within normal range. All the formulations showed good matrix integrity and retarded the release of drug for nine hours. The release pattern of Repaglinide was fitted to different models based on coefficient of correlation (r). All the formulations, except F1 and F2 showed Korsemeyer-Peppas model as the best fit model. Formulation F1 and F2 showed Matrix type model. The formulations F6 was found to be optimized and follows Peppas model for drug release suggesting that the drug release is anomalous from dosage form. The swelling studies of all the formulations showed that formulations containing Xanthan gum has higher swelling indices than Methocel K15M and Methocel K4M. It can be concluded that formulations with higher swelling indices retarded the release of drugs more than those with lower swelling indices.
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